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doi: 10.3390/ijms22158006

GLP-1R agonists could repair mitochondrial damage in vitro , and promote mitochondrial biogenesis and antioxidant system peroxisome proliferator-activated receptor coactivator 1 (PGC-1) signaling pathway in vivo (28)

Inadequate mitochondrial Asp production is an important cause of T cell dysfunction, and lack of aspartate inhibits nicotinamide purine dinucleotide (NADH) production, causing ER expansion and TNF release