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doi: 10.1016/j.biopsycho.2012.03.007, 55

85 A randomized controlled trial in 769 infertile men with low sperm numbers and MTHFR polymorphisms found, in those with the MTHFR 677 TT genotype, 800 mcg (1,360 mcg DFE) folic acid daily for three months improved semen parameters and sperm fragmentation

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This uncertainty further complicates any assessment of combined use