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The majority of skin malignancies, including BCC, malignant melanoma (MM), cSCC, and virus-negative MCC (VN-MCC), also have very high tumor mutational burdens (TMB), which are primarily triggered by UV-signature mutations and contribute to the development of novel tumor-associated epitopes, according to high-throughput sequencing techniques

Nicotinamide-induced mitophagy: event mediated by high NAD+/NADH ratio and SIRT1 protein activation

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