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169 Ghrelin also mediates insulinostatic actions even though human beta-cells do not express any known receptors for ghrelin, but a recent study discovered that the ghrelin receptor is expressed solely by delta-cells, implying that ghrelin dampens insulin secretion by inducing somatostatin release

R.MahajanA.KurilshikovA.Vich VilaA.VsaU.et al (2019)

Chronic low-grade inflammation also has a major role in vascular aging, potentially leading to various age-related diseases, including cardiovascular diseases