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Some genetic variants in GIPR and GLP1R have been associated with differential GLP-1 agonist efficacy in research populations, but individual outcomes depend on dose, diet, exercise, genetics, and medical history combined
Future trials with larger sample sizes will be needed to determine whether semaglutide alone or in combination with other liver-targeted agents will improves outcomes such as liver-related morbidity and mortality in patients with NASH and compensated cirrhosis, Loomba said
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