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Funding This work was supported by grants from the National Natural Science Foundation of China (82203377 to Yanwei Lu

No pathways associated with inflammation were enriched in this analysis

Treatment with picomolar to nanomolar concentrations of Dihexa produces dose-dependent increases in spine density, with maximal effects observed at 10-12 M concentrations

Recent studies have found that increased level of GLP-1 in the hippocampus restores GABA and reverses this neurotoxic effect by reducing oxidative stress through the SIRT1/Nrf2/HO-1 pathway, promoting autophagy through the AMPK/mTOR pathway, and alleviating hippocampal apoptosis by inactivating pro-apoptotic kinase GSK-3 ( The anorectic effects of GLP-1 can also be explained by its GABAergic modulation in the nucleus tractus solitarius (NTS) cells