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The molecule contains three intramolecular disulfide bonds (CysCys linkages), which constrain the peptide into a compact tertiary fold characteristic of the insulin superfamily

The short answer is that both medications can produce significant weight loss, but retatrutide appears to lead to greater average weight reduction in clinical studies because it targets three hormone receptors involved in metabolism rather than one

Corley BT, Carroll RW, Hall RM, Weatherall M, ParryStrong A, Krebs JD

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