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The combined effect of all three pathways creates a metabolic environment that attacks excess body fat from multiple angles simultaneously
According to the results of the RCT for patients with monogenic obesity ( LEPR or POMC deficiency) and acquired hypothalamic obesity, setmelanotide can reduce body weight and inhibit appetite to a certain extent, and common adverse reactions include injection site reactions, skin hyperpigmentation, nausea, diarrhea, and abdominal pain, with occasional occurrences of sexual adverse reactions, depression, and suicidal ideation [51,52]
This was a double-blind study, meaning neither the researchers nor the patients knew which treatment they were receiving
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