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They must also include detailed heavy metal results with detection limits, testing date, and batch identification [10]

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Sarah Armstrong, a member of the AAP guideline committee, stated in a 2023 AAP press briefing: "We do not have the evidence to support pharmacotherapy with GLP-1 agonists below age 12, and clinicians should not extrapolate from adolescent data to younger children without trial-level safety evidence." The Endocrine Society's pediatric obesity guideline similarly restricts pharmacotherapy recommendations to adolescents aged 12 and older when lifestyle interventions have been insufficient [7]

Patients should also inform their healthcare provider if gastrointestinal symptoms significantly impair quality of life or adherence to treatment