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WHAT THIS STUDY ADDS The present post hoc analyses demonstrated that 72-week treatment with tirzepatide was associated with consistent reductions in blood pressure, shifting the blood pressure distribution curve to the left, frequently leading to normalisation of blood pressure values in participants with elevated blood pressure and stage 1 and stage 2 hypertension at baseline, with relatively few blood pressure-related adverse events

AOD-9604 at 300 to 500 micrograms once daily on an empty stomach, ideally 30 minutes before morning exercise