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As a glycolysis byproduct, lactate can induce tumor-associated macrophages (TAMs) and naive macrophages to polarize into M2 macrophages (Morioka et al., 2018) (Figure 2B)

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Am J Prev Med 40:585592 Das J, Ghosh J, Manna P, Sil PC (2010) Taurine protects acetaminophen-induced oxidative damage in mice kidney through APAP urinary excretion and CYP2E1 inactivation