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Neither BPC-157 nor TB-500 is FDA-approved, and the FDA has specifically flagged BPC-157, so these remain research-stage compounds discussed only in a wellness-support context

Hsieh and colleagues (J Mol Med, 2017) reported that BPC 157 upregulated VEGFR2 expression and promoted receptor internalisation and downstream signalling in human umbilical vein endothelial cells, with increased tube formation in vitro and greater vessel density in a rodent hindlimb ischaemia model

Leaving the vial open, even for a short period, can increase the risk of contamination

Effect of cocoa flavanol supplementation for the prevention of cardiovascular disease events: the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial