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Aging (Reduced Synthesis Capacity) As you age, production of glutathione declines due to: Reduced activity of gamma-glutamylcysteine ligase (GCL) , the rate-limiting enzyme in glutathione synthesis Decreased cellular energy (ATP) to fuel glutathione recycling Lower levels of precursor amino acids (especially cysteine and glycine) Studies show glutathione levels drop 10-15% per decade after age 40 [3]

The downstream effect is more dilated vessels and improved local blood flow in injury models

Building upon our previous work using proteolytically activated hydrogels [1419], we envision using fusion proteins to release therapeutic proteins in response to disease-specific proteases