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Based on integrated analyses of gene expression, receptor traffic, and stable isotope tracing of metabolic pathways, constitutively active Rab4A Q72L exerts cell type-specific control over metabolic networks, dominantly impacting CD98-dependent kynurenine production, mTOR activation, mitochondrial electron transport and flux through the tricarboxylic acid cycle and thus expands CD4 + and CD3 + CD4 CD8 double-negative T cells over CD8 + T cells, enhancing B cell activation, plasma cell development, antinuclear and antiphospholipid autoantibody production, and glomerulonephritis in lupus-prone mice

Oferowany jest jako odczynnik chemiczny w ramach obowizujcych w Unii Europejskiej przepisw dotyczcych substancji chemicznych (REACH, CLP)

10.1083/jcb.201007013 J