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The antitumor effects of chronic tirzepatide treatment in obese mice, on colon and breast cancer models are consistent with our findings in a murine model of endometrial cancer 30 , as well as a report by others on liver cancer 36 , and are further supported by reports that significant weight loss (at levels similar to those achieved with tirzepatide) in response to chronic or intermittent calorie restriction or bariatric surgery have anticancer effects in multiple obesity-related cancer models 4446

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NHS guidelines often recommend an initial treatment period of two weeks