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Leptin replacement (r-metHuLeptin) increased the concentration of gray matter in the anterior cingulate gyrus, inferior parietal lobule, and cerebellum, and markedly reduced body weight in the three genetically leptin-deficient adults who had recessive mutations in their ob genes (Matochik et al., 2005)

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Preventive effect of ursodeoxycholic acid on parenteral nutrition-associated liver disease in infants