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Temperature and humidity during production can slightly alter appearance
Importantly, it may refine risk assessment beyond current Kidney Disease: Improving Global Outcomes (KDIGO) guideline parameters, and reduce reliance on invasive biopsies (Kidney Disease: Improving Global Outcomes KDIGO CKD Work Group, 2024)
For example, in a 2021 study, as little as 100mg of dihydroberberine increased berberine blood levels better than 500mg of HCl, and another 2021 study (by Indena, the company that makes Berbevis) found that a phytosomal preparation resulted in a tenfold improvement in bioavailability compared with HCl.48 51 Based on these studies, you might conclude that the two bioenhanced forms are superior to berberine HCl
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