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Animal-model evidence consistently shows local effects: angiogenesis at the injury site (VEGF upregulation), growth-factor signaling (EGF, FGF), nitric oxide pathway modulation, and accelerated tendon-to-bone interface healing in rat Achilles transection studies

Minimum effective frequency is 4 applications per week

After 4 h of treatment with complete DMEM containing 0.1% DMSO or HC, the cellular monolayer was washed two times with DPBS, detached using 0.5% trypsin-EDTA and centrifuged at 1,000 g for 10 min

Antioxidant Protection Epitalon has demonstrated the ability to reduce oxidative stress, which contributes to DNA damage and mitochondrial dysfunction