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176,177 It will further fail when attempting to describe how allosteric rescue mutations 178,179 work (albeit not other rescue mutations, e.g., refs (180183)), how allosteric drugs are able to block the active site, and how mutations countering them can be overcome
Peptides A6A8 carrying charges of +5, +4, and +3 respectively, which are obtained by the substitution of Lys4, Lys4Arg11, or Lys4Arg6Arg11 of A4 with L -alanine, showed gradually decreasing cell penetration ability compared with A4 with +6 positive charges (Figure 11C)
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This material is intended strictly for in-vitro research use
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