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Chow-fed mice with KO of Gipr in GABAergic neurones achieved by crossing Gipr fx/fx with VGAT-Cre strains, were also previously reported to have normal body weight, although with subtle differences in fat mass and respiratory exchange ratio (RER), and improved glucose metabolism 5,11

Endpoints The primary endpoint was flow-mediated dilation (FMD) percentage change in cohort at the 24th week of the study

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Zeisberg M, Yang C, Martino M, Dunca M, Rieder F, Tanjore H, Kalluri R (2007)