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In ex vivo hHF organ culture model, 25 M P5 treatment significantly promoted hair shaft growth

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These molecules have a strong affinity for the estrogen receptors (ERs) ER, ER, and G-protein coupled ER1 (GPER1), through which, after binding, induce a direct or indirect genomic signaling to change the expression pattern of several genes (Fuentes and Silveyra, 2019)