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Humans express three malic enzymes, one cytoplasmic that requires NADP + and two mitochondrial enzymes, one that requires NADP + and one that requires NAD +
Recent studies have demonstrated that BMSC-Exos can promote neurological recovery in ASCI by inhibiting ferroptosis through the Nrf2/GTP cyclohydrolase I (GCH1)/5,6,7,8-tetrahydrobiopterin (BH4) signaling axis, reducing oxidative stress, and enhancing the expression of ferroptosis suppressors [146]
Atherosclerosis affects the limbs, but more frequently the legs, and can cause pain, muscle cramps, and numbness
doi: 10.3390/ijms241814126
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