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Along the vascular lumen, endothelial XO/XDH and NOX1/NOX4 tune nitric-oxide bioavailability through competing O 2 /H 2 O 2 fluxesO 2 scavenges NO to form peroxynitrite (ONOO ), blunting vasodilation, whereas controlled H 2 O 2 can serve as an endothelium-derived hyperpolarizing factor and redox cue for smooth-muscle relaxationso that shifts in enzyme activity, shear stress, or metabolic inputs quickly translate into changes in vascular reactivity and oxidative burden (Konstandin et al

Clinical research in cardiology supplements 10, 338 (2015)

The ida icd 10 family stays unchanged for the FY2026 cycle

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