Oftentimes, too-high levels of oxidative stress and Glutathione depletion can lead to multiple diseases, including neurodegenerative disorders (Alzheimers, Parkinsons), pulmonary disease (asthma, COPD), immune disease (HIV, autoimmune disease), cardiovascular diseases (hypertensions), liver disease, cystic fibrosis, and aging
Potential mechanisms identified underlying this include an increase in the risk factors for both uric acid and calcium oxalate kidney stones
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In fact, treatment with the bacterium Akkermansia muciniphila diminished the inducement of a depression-like behavior caused by chronic stress, where the regulation of this metabolic profile stands on such variables as acute corticosterone, dopamine, and BDNF (Ding et al., 2021)