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subjects with obesity may be due to the indirect effect of improved glucose control on body weight homeostasis

Even a mid-cap that introduces an objectively better-performing drug could face difficulty competing against established brand names

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As an example, in the DURATION-8 study, while combination therapy produced greater HbA1c and body weight reductions, the effect was less than additive compared to the sum of individual drug effects, most likely because the efficacy of glucose-lowering therapies can depend on baseline glycaemic control [24]