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99,219 In excitatory neurons, CaMKII functions as a shuttle molecule to collect Ca 2+ /Calmodulin from the cytoplasm and transport it to the nucleus, where Ca 2+ /Calmodulin release activates CaMKK and its substrate CaMKIV to further phosphorylate CREB, thereby participating in the regulation of transcription and translation

Fat metabolism: GH enhances lipolysis (fat breakdown), potentially complementing semaglutide's weight loss effects while shifting the ratio toward fat loss rather than muscle loss

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