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However, several clinical studies and animal experiments have demonstrated that concussion rehabilitation that includes various forms of early introduction of PE improves mobility [115], balance ability [116], and mood, and reduces post-concussion symptoms such as depression [117], although the clinical application of exercise rehabilitation in TBI remains challenging, particularly due to the lack of a clinical evaluation system [8]

Phase 3 trial results (REDEFINE program) showed CagriSema produced approximately 22-25% body weight reduction, putting it in direct competition with tirzepatide and retatrutide

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