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Although IFN- augments the anti-tumor efficacy of CD8 + T cells, the tumor immune microenvironment (TIME) considerably affects this mechanism, possibly restricting ferroptosis in immunologically inert malignancies (57, 58)

For example, downregulated CTR1 expression has been confirmed in cisplatin-resistant ovarian cancer cell lines, which directly leads to reduced drug uptake and insufficient platinum accumulation in tumor cells, ultimately triggering chemotherapy resistance (Kalayda et al

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