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Since the exact risk factors may be hard to establish, treatment can be challenging [15]

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In a mouse model relevant to myalgic encephalomyelitis/chronic fatigue syndrome rather than FM, combined lipopolysaccharide administration and swim stress activated the diencephalic NLRP3 inflammasome, leading to caspase-1-mediated IL-1 maturation and fatigue-like motor deficits, while lactate and MDA levels remained unchanged

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