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Nonclinical studies in rodents of clinically relevant doses of GLP-1 receptor agonists showed dose-related and treatment-duration-dependent increases in the incidence of thyroid C-cell tumors (adenomas and carcinomas)

They work through different pathways and are not interchangeable

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In parallel, machine learning methods and structural equation modeling (SEM) offer robust strategies to predict phenotypes and interpret causal relationships between molecular variables and performance (Liang et al