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M1 macrophages participate in extensive tissue remodeling via the secretion of matrix metalloproteinases upon trophoblast invasion, while M2 macrophages are activated by secreted factors from trophoblasts such as placental-specific glycoproteins (PSGs), M-CSF, TGF-, IL-10, IL-34, and sHLA-G5 and support angiogenesis through the secretion of VEGF

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