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These include studies like SUSTAIN, PIONEER, and STEP

Contrave is intended for adults aged 18 and over who have a body mass index (BMI) of 30 or greater (obesity), or a BMI of 27 or greater (overweight) along with at least one weight-related health condition like high blood pressure, type 2 diabetes, or high cholesterol

The combination of reduced protective factors (less saliva, fewer nutrients) and decreased defensive measures (less careful oral hygiene) creates the perfect storm for rapid dental deterioration

Left ventricular end systolic diameter (LVESD), and left ventricular end diastolic diameter (LVEDD) were measured from 2D long-axis views under M-mode tracings at the level of the left ventricular tendons