In this manuscript, we propose that an integrative neurogenomics workflowcombining multi-omic phenotypeoriented whole-exome sequencing, biologically-oriented common variant burden profiling, biochemical markers, functional metagenomic data, and multidisciplinary clinical interpretationcan generate testable, personalized diagnostic and therapeutic hypotheses in neurodegenerative disorders
9f,g) were highly enriched in cell surface proteins, with 9092% of entries having prior cell surface annotation (Fig
These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione
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