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The role of the gut microbiome in pediatric obesity One of the most crucial worldwide health issues that has become more common over the past ten years is pediatric obesity

Impaired kidney function, cerebral small vessel disease and cognitive disorders: the Framingham Heart Study

The study included patients with renal impairment classified on the basis of creatinine clearance as mild (greater or equal to 50 and less than 80 mL/min), moderate (greater than or equal to 30 and less than 50 mL/min), and severe (less than 30 mL/min)

A aggregation and tau hyperphosphorylation can disrupt the calcium balance in neurons, leading to mitochondrial calcium overload, increased reactive oxygen species production, reduced ATP generation, and ultimately, neuronal apoptosis or necrosis [76, 77]