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A study analyzing skin cancer incidence in patients with Lynch syndrome suggested that there was an increase in sebaceous carcinomas and SCCs.[23] Additional studies are needed to determine if pathogenic variants in the Lynch syndrome genes cause SCC.[17] Hereditary Leiomyomatosis and Renal Cell Carcinoma (HLRCC) Although cutaneous smooth muscle tumors (leiomyomas) are not themselves a form of skin cancer, multiple cutaneous leiomyomas are associated with renal cell cancer (RCC) in an inherited syndrome known as hereditary leiomyomatosis and renal cell cancer (HLRCC)

Importantly, a pilot study in older adults with T2DM and obesity reported that semaglutide preserved the SMM percentage of the extremities despite a decrease in total muscle mass [55]

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