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Genomic profiling published by Pickart and colleagues identified expression changes across roughly 4,000 human genes, spanning extracellular matrix biology, antioxidant defense, DNA repair, and tumor suppressor pathways

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In the years immediately following the IOMs 1998 report setting the current RDA, research associated an abnormally high level of homocysteine, a molecule involved in protein metabolism, with an increased risk of cardiovascular disease, mortality, and cognitive impairment

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