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As mentioned, a secondary analysis of an RCT assessing the cardiometabolic effects of exenatide in 40 people with schizophrenia 140 also looked at measures of cognition and psychosocial functioning (that is, Brief Assessment of Cognition in Schizophrenia, ReyOsterreith Complex Figure Test, Short-Form Health Survey, Personal and Social Performance Scale, Positive and Negative Syndrome Scale), but found no effect for this GLP-1RA compared with placebo over 3 months 133

This pathway helps regulate antioxidant enzymes and supports the bodys natural detoxification systems

Rather than targeting GLP-1 receptors alone, it's a dual agonist activating both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors simultaneously

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