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The top lipid metabolite 8-HETE (8-Hydroxyeicosatetraenoic Acid), an oxidized lipid mediator, modulates GLP1R sensitivity and signaling, influencing metabolic responses and insulin secretion dynamics 82

This review underscores the potential for integrated strategies targeting liver-brain crosstalk to mitigate neurodegeneration

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In the landmark SELECT trial in 2023, the scope of GLP-1RAs was expanded to assess cardiovascular risk in patients with preexisting cardiovascular disease who were overweight or obese without type 2 diabetes [48]