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Liver-expressed antimicrobial peptide 2 (LEAP-2), the endogenous noncompetitive allosteric antagonist of the growth hormone secretagogue receptor 1a (GHSR1a), was recently identified as a key endocrine factor regulating systemic energy metabolism

These situations require prompt medical assessment

This review comprehensively summarizes the role of mitophagy in metabolic diseases, the effects of different types of exercise on mitophagy, and the potential mechanisms of exercise-regulated mitophagy intervention in metabolic diseases, providing new insights for basic and clinical research on exercise intervention for preventing and treating metabolic diseases