"As a medical community we are obtaining a better understanding of the physiology and hormones that create and maintain weight gain and this is allowing for improved treatment options of a complex medical condition
Why can't the large semaglutide and tirzepatide trials settle the IBS question
This may include people who: Are early in treatment Recently changed their dose Already have nausea, vomiting, reflux, diarrhea, or constipation Have trouble staying hydrated Have diabetes or take blood sugar-lowering medication Have a history of pancreatitis Have gallbladder disease or gallstones Have liver disease or abnormal liver enzymes Drink heavily or binge drink Have a history of alcohol use disorder Are pregnant, trying to become pregnant, or breastfeeding Are taking other medications that interact with alcohol If any of these apply to you, do not guess
GLP-1 receptor agonists slow gastric emptying and suppress appetite, which can reduce energy intake and cause fatigue Fatigue is most common during initial weeks and dose increases, often improving as the body adapts over several weeks to months Nutritional deficiencies in protein, iron, vitamin D, and B vitamins may develop when food intake drops significantly Optimising nutrition with nutrient-dense foods, maintaining hydration, and gentle physical activity can significantly reduce tiredness Contact your GP if fatigue is severe, worsening, or accompanied by signs of dehydration, hypoglycaemia, or persistent gastrointestinal symptoms Table of Contents Why GLP-1 Medications Can Cause Tiredness Glucagon-like peptide-1 (GLP-1) receptor agonists are increasingly prescribed medications for type 2 diabetes and weight management, including semaglutide (Ozempic, Wegovy) and liraglutide (Victoza, Saxenda)
