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In a double-blind, randomized, placebo-controlled multi-site study for three months, anatabine treated patients had a significant reduction in absolute serum TgAb levels from baseline by study end relative to those on placebo (p=0.027) (108.9)

Many patients in the trial were also receiving standard-of-care therapies for their underlying cardiovascular disease, with 90.1% of patients taking lipid-lowering medications, 86.2% antiplatelets, 70.2% beta-blockers, 45.0% ACE inhibitors and 29.5% ARBs