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This finding agrees with the literature whereby the role of quinone redox metabolism is an ambiguous source of toxicity, with evidence suggesting that redox cycling requires supra-pharmacological concentrations of doxorubicin to generate substantial ROS in tissues and cells 10

Reduced glutathione is an antioxidant that can improve the damage to the liver caused by various adverse factors by maintaining the normal metabolism of cells in the body, eliminating oxygen free radicals, and other biochemical metabolic reactions [15,16,17]

10.1016/j.bbi.2020.07.015 37 El HajjS.Canabady-RochelleL.GaucherC