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*Correspondence: Christian Hlscher, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Hormone Replacement Therapy may support: Increased energy and mental clarity Improved sleep and mood balance May support a healthy sex drive as part of overall hormonal balance Preservation of lean muscle mass Enhanced metabolic efficiency Overall vitality and well-being Why Pair GLP-1 Therapy with HRT

That result is genuinely notable, but it is also frequently over-interpreted

Their primary mechanisms of action include: Stimulating insulin secretion from pancreatic beta cells in a glucose-dependent manner Suppressing glucagon release , which reduces glucose production by the liver Slowing gastric emptying , which helps control post-meal blood sugar rises Reducing appetite through effects on brain centres that regulate hunger In the UK, GLP-1 receptor agonists are licensed for the treatment of type 2 diabetes mellitus and, in some cases, for weight management in adults with obesity or overweight with weight-related comorbidities