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Studies in mice have shown that ASK-1 promotes TNF--mediated IR and steatosis (263), whereas inhibition of ASK1 ameliorates diet-induced steatosis and fibrosis (264)

But for Hashimoto's patients, who already have compromised thyroid tissue and may have a higher baseline risk of thyroid nodules, this is not something to dismiss casually

Folate is important for brain and nervous system development, which is why pregnant women are often prescribed supplements that contain folic acid, a synthetic version of folate