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In the first casewhen drug concentrations are dangerously increasedcertain compounds in the fruit known as furanocoumarins inhibit the action of an enzyme, called CYP3A4, which occurs in the small intestine

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Recently, the dual GIPR/GLP-1R co-agonist, tirzepatide, has demonstrated a marked effect on body weight in individuals with overweight and obesity, and Phase III trials of this drug are expected to be completed in 2023 [28]