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Tissue proliferation markers remained constant

Biguanides were derived from plants used to treat diabetes in antiquity before the era of targeted drug development (12)

Contact your doctor if: Fatigue is severe enough to interfere with daily activities You experience dizziness, confusion, or extreme weakness Symptoms don't improve after several weeks You're on multiple medications that might be contributing to fatigue Your provider might recommend blood tests to check for other causes of fatigue, such as anemia, thyroid issues, or vitamin deficiencies