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And yet the conjugate fires POMC (pro-opiomelanocortin) neurons in the arcuate nucleus of the hypothalamus harder than the GLP-1/GIP backbone alone, as measured by both in vivo fiber photometry in Pomc-cre mice and ex vivo whole-cell patch recordings in Pomc-GFP mice

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This combination is designed to support weight loss and overall well-being, particularly for individuals who may be at risk of B12 deficiency

The life expectancy of patients with T2D is typically reduced by up to 10 years (Waugh et al., 1989), while a study reported that diabetic patients treated with metformin monotherapy had longer survival rates than a matched, non-diabetic control (Bannister et al., 2014)