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It is still being excavated, so there are uncleared areas

In some mild cases, it is enough, but for more complicated metabolic disorders like tetanus and paresis, treatment with calcium and magnesium are also recommended

While studies explore plausible mechanisms (NO-system modulation, VEGFR2-Akt-eNOS signaling, GHR/JAK2 in tendon cells), well-controlled human trials are limited

Chandys hypothesis, that the rapid onset of the repairing processes induced by B12 shots might overwhelm the system and temporarily cause a worsening in symptoms, similar to the Jarisch-Herxheimer reaction in those treated for Lyme disease