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10.1155/2021/9221693 Oxid Med Cell Longev

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Research indicates a significant decline in NAD+ production and availability as we age, a phenomenon exacerbated by lifestyle factors such as chronic stress, poor diet, excessive alcohol consumption, and lack of physical activity

PMID: Summary Keywords high-altitude cognitive dysfunction, inflammation, oxidative stress, PI3K/Akt signaling pathway, transcriptomic analysis Citation Xin Y, Yang C, Wang G, Ma H and Jing L (2026) Transcriptomic analysis and experimental verification reveal the involvement of PI3K/AKT signaling pathway in high-altitude cognitive dysfunction