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Since most ingested allulose is absorbed and excreted in urine, with only a fraction reaching the colon, the direct microbiome effects may be less significant than initially hypothesized

Absence of glucagon and insulin action reveals a role for the GLP-1 receptor in endogenous glucose production

This piece in 1993 also provided new insights into the biology of exendin, namely that exendin-4 was a full agonist of the human GLP-1 receptor, which Mojsov argues was crucial to convincing Amylin to develop exendin as a drug for diabetes (see below)

Earlier-generation compounds in the GLP-1 class operate on one receptor (Semaglutide, a GLP-1 mono-agonist) or two (Tirzepatide, a dual GLP-1/GIP receptor agonist)